Alzheimercentrum Amsterdam

Recruitment & visits

Wie mag deelnemen? 1


We generate attention for the 100-plus Study in several types of media and we distribute written study information to motivate CHCs or their relations to contact us. We also approach CHCs whose 100th birthday is reported in local newspapers by sending them an information flyer and information letter. Within two weeks, we call the CHC or their contact person. When interested in participation, we plan two home visits and ask if family members who are interested in participating can be present at one of these visits.

Home visits

Study participation includes two home visits. These home visits are usually one week apart.

The first visit takes approximately 2 to 3 hours and comprises an extensive interview; the evaluation of the participant’s genealogy, their overall life history, socio-economic (education, occupation), lifestyle (smoking habits and alcohol consumption) and medical history from birth, early childhood to adulthood and current (old) age, including weight and length. We register use of prescribed medication, including vitamins. Also, we evaluate living circumstances during their lifetime and the current level of independence. We estimate and record visual and auditory functioning in daily living. We obtain a written informed consent to participate in the study.

The second visit takes approximately 1.5 hours. During this visit the researcher will subject the CHC to a battery of neuropsychological tests to generate a cognitive profile.  We administer a test battery which assesses overall cognitive functioning, memory, executive functioning and visuospatial functioning. Furthermore, we administer self-report questionnaires to assess lifetime cognitively stimulating experience, sleeping, and symptoms of depression, and we ask a close relation to report any notion of changes in cognitive functioning. During testing, participants are encouraged to use all available devices to support their vision/hearing. Moreover, we measure grip strength and blood pressure. During this second visit we will also discuss the possibility to participate in optional elements of the 100-plus Study. Optional parts of the study are mentioned under ‘First phase in 2013’ and ‘Second phase in 2017’.

During either the first or second visit, a blood sample will be obtained from the CHC. If first-degree family members of the CHC also consent to study participation we prefer to obtain a blood sample during the same visit.